La única opción que se me ocurre sería cambiar los accesos directos predeterminados a algo como ⌃⌥⇧⌘ + números y guardar esto como private.xml en KeyRemap4MacBook.
<?xml version="1.0"?>
<root>
<item>
<name>test</name>
<identifier>private.test</identifier>
<autogen>--KeyToKey-- KeyCode::KEY_1, VK_OPTION | VK_COMMAND, KeyCode::KEY_1, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_2, VK_OPTION | VK_COMMAND, KeyCode::KEY_2, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_3, VK_OPTION | VK_COMMAND, KeyCode::KEY_3, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_4, VK_OPTION | VK_COMMAND, KeyCode::KEY_4, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_5, VK_OPTION | VK_COMMAND, KeyCode::KEY_5, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_6, VK_OPTION | VK_COMMAND, KeyCode::KEY_6, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_7, VK_OPTION | VK_COMMAND, KeyCode::KEY_7, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_8, VK_OPTION | VK_COMMAND, KeyCode::KEY_8, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_9, VK_OPTION | VK_COMMAND, KeyCode::KEY_9, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_0, VK_OPTION | VK_COMMAND, KeyCode::KEY_0, VK_CONTROL | VK_OPTION | VK_SHIFT | VK_COMMAND</autogen>
</item>
<item>
<name>test2</name>
<identifier>private.test2</identifier>
<only>GOOGLE_CHROME</only>
<autogen>--KeyToKey-- KeyCode::KEY_1, VK_CONTROL | VK_OPTION, KeyCode::KEY_1, VK_OPTION | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_2, VK_CONTROL | VK_OPTION, KeyCode::KEY_2, VK_OPTION | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_3, VK_CONTROL | VK_OPTION, KeyCode::KEY_3, VK_OPTION | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_4, VK_CONTROL | VK_OPTION, KeyCode::KEY_4, VK_OPTION | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_5, VK_CONTROL | VK_OPTION, KeyCode::KEY_5, VK_OPTION | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_6, VK_CONTROL | VK_OPTION, KeyCode::KEY_6, VK_OPTION | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_7, VK_CONTROL | VK_OPTION, KeyCode::KEY_7, VK_OPTION | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_8, VK_CONTROL | VK_OPTION, KeyCode::KEY_8, VK_OPTION | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_9, VK_CONTROL | VK_OPTION, KeyCode::KEY_9, VK_OPTION | VK_COMMAND</autogen>
<autogen>--KeyToKey-- KeyCode::KEY_0, VK_CONTROL | VK_OPTION, KeyCode::KEY_0, VK_OPTION | VK_COMMAND</autogen>
</item>
</root>
Consulte la fuente de las constantes de código clave y configuración predefinida .